Tamoxifen 40 mg- Tamoxifen citrate is a non-steroidal anti-estrogen drug, it is widely used in clinical medicine. Classify it as a selective regulator of estrogen receptor activity, with agonistic and antagonistic properties. The chemical formula (Z) is 2- [4-1,2-diphenyl-1-butenyl) phenoxy] -N, N-dimethylethanamine-2-hydroxy-1,2,3-propane tetricarboxylate.
For the first time tamoxifen was synthesized in 1962, the company did it ICI. Used in the USA to treat some forms of infertility in women. Since 1971, it began to be used in the treatment of breast cancer. Since 1977, the drug enters the markets in many countries under various names, begins to be popular.
Pharmacological action (according to the manufacturer)
Tamoxifen is referred to as nonsteroidal anti-estrogen drugs, despite this, it has weak estrogenic properties. The action of the drug is based on the ability to block estrogen receptors. Tamoxifen and some of its metabolites compete with estradiol for binding sites to the cytoplasmic estrogen receptors in the tissues of the breast, uterus, vagina, anterior pituitary gland and tumors with a high content of estrogen receptors. Unlike the estrogen receptor complex, the tamoxifen receptor complex does not have a stimulating effect on DNA synthesis in the nucleus, it inhibits cell division, and this leads to regression of tumor cells, and subsequently death.