Regulate the development and preservation of the function of the female reproductive system, the formation of secondary sexual characteristics.
Manifestations of climacteric syndrome are relieved or suppressed – vasomotor disorders, emotional (irritability, anxiety, depression) and urogenital (atrophic vaginitis, progressive diffuse atrophy of the external genital organs) symptoms.
They prevent the development of postmenopausal osteoporosis, increase HDL levels, decrease LDL and total cholesterol, and reduce the risk of cardiovascular diseases.
The components of the drug are soluble in water and are well absorbed in the gastrointestinal tract, penetrate into the target tissues (genitals, mammary glands, bones, hypothalamus, pituitary gland), cytoplasm and cell nuclei, where they stimulate the synthesis of RNA and protein.
Biotransformation occurs mainly in the liver, estrogens are excreted in the bile, but are reabsorbed from the intestines and returned to the portal vein system. Water-soluble estrogen conjugates with acidic properties are ionized in the body and excreted by the kidneys with minimal reabsorption in the tubules.
INDICATIONS FOR USE
Menopausal syndrome, estrogen insufficiency in the menopausal and postmenopausal period, postmenopausal osteoporosis, dysfunctional uterine bleeding, dysmenorrhea, amenorrhea, prostate cancer.
Breast cancer and estrogen-dependent neoplasms; uterine bleeding of unknown etiology; thrombophlebitis, a violation of the blood coagulation system, thromboembolic diseases; severe diseases of the cardiovascular system; severe impaired liver or kidney function; sickle cell anemia; congenital hearing loss; long immobilization.
Headache, nausea, vomiting, weight gain, edema, uterine bleeding, facial skin pigmentation, erythema nodosum, transient increase in plasma levels of transaminases, hyperbilirubinemia; allergic reaction (rash); rarely – hemorrhagic skin rash, endometrial tumors.